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Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

Abstract : Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action whereas plasma membrane-located ERα accelerates endothelial healing. The genetic deficiency of ERα was associated with a reduction in flow-mediated dilation (FMD) in one man. Here, we evaluated ex vivo the role of ERα on FMD of resistance arteries. FMD, but not agonist (acetylcholine, insulin)-mediated dilation, was reduced in male and female mice lacking ERα ( Esr1 -/- mice) compared to wild-type mice and was not dependent on the presence of estrogens. In C451A-ERα mice lacking membrane ERα, not in mice lacking AF2-dependent nuclear ERα actions, FMD was reduced, and restored by antioxidant treatments. Compared to wild-type mice, isolated perfused kidneys of C451A-ERα mice revealed a decreased flow-mediated nitrate production and an increased H 2 O 2 production. Thus, endothelial membrane ERα promotes NO bioavailability through inhibition of oxidative stress and thereby participates in FMD in a ligand-independent manner.
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https://hal.univ-angers.fr/hal-03483155
Contributeur : Daniel Henrion Connectez-vous pour contacter le contributeur
Soumis le : jeudi 16 décembre 2021 - 12:27:13
Dernière modification le : vendredi 1 avril 2022 - 03:52:33

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Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, et al.. Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner. eLife, eLife Sciences Publication, 2021, 10, pp.e68695. ⟨10.7554/eLife.68695⟩. ⟨hal-03483155⟩

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