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Caractérisation de l’activité du cortex sensorimoteur, par électroencéphalogramme haute densité (EEG-hd), chez le jeune enfant avec paralysie cérébrale et atteinte unilatérale spastique

Abstract : Cerebral palsy (CP) describes a group of sensorimotor disorders and is the consequence of an early brain injury. Unilateral cerebral palsy (UCP) represents 30% of individuals with CP. The study of markers of neuroplasticity could help to validate early motor therapies by clarifying their effects. Electroencephalography (EEG) is used to investigate the sensorimotor brain system, but there are few studies in children with UCP, and even fewer using high-density EEG (hdEEG), which allows better spatial resolution. Moreover, they are studying only the modulations of the mu rhythm The main objective of this thesis is to characterize the sensorimotor cortex activity using hdEEG in young children with UCP by developing paradigms of EEG signal acquisition designed to study three types of electrophysiological signals considered to be of potential interest: the cortico kinematic coherence (CKC), the mu rhythm, and the resting state functional connectivity. First, a literature review was performed based on 16 observational studies and showed that in adolescent individuals with UCP, the mu rhythm is found in almost all participants but presents atypical modulation patterns. Next, CKC was analyzed in 12 preschool children with UCP in the lesioned and non-lesioned hemispheres. This study showed that spino-cortical proprioceptive processing is impaired in the lesioned hemisphere, particularly in children with cortico subcortical lesions. Finally, preliminary results of mu rhythm reactivity obtained in 7 children with PCU showed desynchronization that more marked in the non lesioned hemisphere in most cases, and almost no post-movement resynchronization. In conclusion, the sensorimotor cortex activity can be studied in infants and young children with UCP using hd-EEG. Further studies are needed to clarify the test-retest reliability of these signals in this population, as well as the contribution of the study of resting-state functional connectivity
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Submitted on : Wednesday, May 25, 2022 - 3:25:11 PM
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  • HAL Id : tel-03678759, version 1

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Josselin Demas. Caractérisation de l’activité du cortex sensorimoteur, par électroencéphalogramme haute densité (EEG-hd), chez le jeune enfant avec paralysie cérébrale et atteinte unilatérale spastique. Autre. Université d'Angers, 2021. Français. ⟨NNT : 2021ANGE0043⟩. ⟨tel-03678759⟩

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